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KMID : 0854720110310030207
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Korean Journal of Asthma, Allergy and Clinical Immunology
2011 Volume.31 No. 3 p.207 ~ p.214
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Therapeutic Effects of Light Emitting Diode on Atopic Dermatitis-Like Lesions in NC/Nga Mice
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Lim Yun-Young
Jang Woo-Sun
Kim Hyeong-Mi
Kim In-Su
Lee Jin-Woong
Kim Myeung-Nam
Kim Beom-Joon
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Abstract
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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is caused by immunological abnormalities, abnormalities of the skin barrier, and environmental/genetic factors. We did a preclinical trial to identify the effects of the 633-nm light- emitting diode (LED) and 830-nm LED for AD-like lesions in NC/Nga mice.
Methods: AD-like skin lesions were induced by topical application of Dermatophagoides farinae extract on the skin of 5-week-old NC/Nga mice for 2 weeks, and then was treated with 630-nm or 830-nm LED for 1 week. We identified any therapeutic effects on AD using modified SCORAD index, skin biopsy, and measurements of both transepidermal water loss (TEWL) and proinflammatory cytokines.
Results: Both of 630-nm and 830-nm LED treatment groups showed significantly reduced SCORAD indices and TEWLs at the end of treatment, compared to the non-treatment group. In addition, the levels of proinflammatory cytokine levels in both of the LED treatment groups were significantly decreased compared to those in the non-treatment group.
Conclusion: These results show that 633-nm and 830-nm LED treatments can improve -like lesions in NC/Nga mice.
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KEYWORD
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Visible Light, Atopic dermatitis
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